LMPD Database

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LMP009167

Gene Information

Entrez Gene ID31014
Gene NameCG16982 gene product from transcript CG16982-RC
Gene SymbolRoc1a
SpeciesDrosophila melanogaster
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IEA:UniProtKB-KWCcytoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0019005 IDA:UniProtKBCSCF ubiquitin ligase complex
GO:0004842 IDA:FlyBaseFubiquitin-protein transferase activity
GO:0008270 NAS:UniProtKBFzinc ion binding
GO:0008283 IMP:FlyBasePcell proliferation
GO:0019915 IDA:FlyBasePlipid storage
GO:0030178 IMP:FlyBasePnegative regulation of Wnt signaling pathway
GO:0022008 IMP:FlyBasePneurogenesis
GO:0016322 IMP:FlyBasePneuron remodeling
GO:0016567 IDA:FlyBasePprotein ubiquitination
GO:0006508 IMP:FlyBasePproteolysis
GO:0007224 NAS:UniProtKBPsmoothened signaling pathway
KEGG Pathway Links
KEGG Pathway IDDescription
dme_M00384Cul3-SPOP complex
M00384Cul3-SPOP complex
dme_M00383ECV complex
M00383ECV complex
dme03420Nucleotide excision repair
ko03420Nucleotide excision repair
dme04141Protein processing in endoplasmic reticulum
ko04141Protein processing in endoplasmic reticulum
dme_M00380SCF-BTRC complex
M00380SCF-BTRC complex
dme_M00387SCF-FBW7 complex
M00387SCF-FBW7 complex
dme_M00381SCF-SKP2 complex
M00381SCF-SKP2 complex
dme04350TGF-beta signaling pathway
ko04350TGF-beta signaling pathway
dme04120Ubiquitin mediated proteolysis
ko04120Ubiquitin mediated proteolysis
dme04310Wnt signaling pathway
ko04310Wnt signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
6226444AMER1 mutants destabilize the destruction complex
6226451APC truncation mutants are not K63 polyubiquitinated
6226452APC truncation mutants have impaired AXIN binding
6226453AXIN missense mutants destabilize the destruction complex
6226440AXIN mutants destabilize the destruction complex, activating WNT signaling
6226062Cellular responses to stress
6226838Cellular response to hypoxia
6226972Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
6226971Constitutive Signaling by NOTCH1 PEST Domain Mutants
6226118Cytokine Signaling in Immune system
6226439Degradation of beta-catenin by the destruction complex
6226891degradation of DVL
6226454deletions in the AMER1 gene destabilize the destruction complex
6226455deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
6225885Disease
6226243FBXW7 Mutants and NOTCH1 in Cancer
6226003Immune System
6226754Interleukin-1 signaling
6226973Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
6226446misspliced GSK3beta mutants stabilize beta-catenin
6226518misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
6226921NOTCH1 Intracellular Domain Regulates Transcription
6226836Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
6226442phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
6226837Regulation of Hypoxia-inducible Factor (HIF) by oxygen
6226519RNF mutants show enhanced WNT signaling and proliferation
6226447S33 mutants of beta-catenin aren't phosphorylated
6226448S37 mutants of beta-catenin aren't phosphorylated
6226449S45 mutants of beta-catenin aren't phosphorylated
6226117Signaling by Interleukins
6226240Signaling by NOTCH
6226239Signaling by NOTCH1
6226245Signaling by NOTCH1 HD Domain Mutants in Cancer
6226246Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
6226242Signaling by NOTCH1 in Cancer
6226241Signaling by NOTCH1 PEST Domain Mutants in Cancer
6226244Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
6226300Signaling by Wnt
6226441Signaling by WNT in cancer
6225975Signal Transduction
6226450T41 mutants of beta-catenin aren't phosphorylated
6226445TCF7L2 mutants don't bind CTBP
6226517TCF dependent signaling in response to WNT
6226443truncated APC mutants destabilize the destruction complex
6226456truncations of AMER1 destabilize the destruction complex
6226520XAV939 inhibits tankyrase, stabilizing AXIN