LMPD Database

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LMP006799

Record overview

LMPD IDLMP006799
Gene ID51601
SpeciesHomo sapiens (Human)
Gene Namelipoyltransferase 1
Gene SymbolLIPT1
Synonyms-
Alternate nameslipoyltransferase 1, mitochondrial; lipoyl ligase; lipoate biosynthesis protein
Chromosome2
Map Location2q11.2
EC Number2.3.1.-
SummaryThe process of transferring lipoic acid to proteins is a two-step process. The first step is the activation of lipoic acid by lipoate-activating enzyme to form lipoyl-AMP. For the second step, the protein encoded by this gene transfers the lipoyl moiety to apoproteins. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 13. Read-through transcription also exists between this gene and the neighboring downstream mitochondrial ribosomal protein L30 (MRPL30) gene. [provided by RefSeq, Mar 2011]
OrthologsView orthologs and multiple alignments for LIPT1

Proteins

lipoyltransferase 1, mitochondrial precursor
Refseq ID:NP_660198
Protein GI:21729880
UniProt ID:Q9Y234
mRNA ID:NM_145197
Length:373
RefSeq Status:REVIEWED
MLIPFSMKNCFQLLCNCQVPAAGFKKTVKNGLILQSISNDVYQNLAVEDWIHDHMNLEGKPILFFWQNSPSVVIGRHQNPWQECNLNLMREEGIKLARRR
SGGGTVYHDMGNINLTFFTTKKKYDRMENLKLIVRALNAVQPQLDVQATKRFDLLLDGQFKISGTASKIGRTTAYHHCTLLCSTDGTFLSSLLKSPYQGI
RSNATASIPSLVKNLLEKDPTLTCEVLMNAVATEYAAYHQIDNHIHLINPTDETLFPGINSKAKELQTWEWIYGKTPKFSINTSFHVLYEQSHLEIKVFI
DIKNGRIEICNIEAPDHWLPLEIRDKLNSSLIGSKFCPTETTMLTNILLRTCPQDHKLNSKWNILCEKIKGIM
 
lipoyltransferase 1, mitochondrial precursor
Refseq ID:NP_057013
Protein GI:7706252
UniProt ID:Q9Y234
mRNA ID:NM_015929
Length:373
RefSeq Status:REVIEWED
Protein sequence is identical to GI:21729880 (mRNA isoform)
 
lipoyltransferase 1, mitochondrial precursor
Refseq ID:NP_660199
Protein GI:21729882
UniProt ID:Q9Y234
mRNA ID:NM_145198
Length:373
RefSeq Status:REVIEWED
Protein sequence is identical to GI:21729880 (mRNA isoform)
 
lipoyltransferase 1, mitochondrial precursor
Refseq ID:NP_001191759
Protein GI:325651943
UniProt ID:Q9Y234
mRNA ID:NM_001204830
Length:373
RefSeq Status:REVIEWED
Protein sequence is identical to GI:21729880 (mRNA isoform)
 
lipoyltransferase 1, mitochondrial precursor
Refseq ID:NP_660200
Protein GI:21729884
UniProt ID:Q9Y234
mRNA ID:NM_145199
Length:373
RefSeq Status:REVIEWED
Protein sequence is identical to GI:21729880 (mRNA isoform)
 
transit_peptide: 1..25
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q9Y234.1)
calculated_mol_wt: 2804
peptide sequence: 
MLIPFSMKNCFQLLCNCQVPAAGFK

mat_peptide: 26..373
product: Lipoyltransferase 1, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q9Y234.1)
calculated_mol_wt: 39693
peptide sequence: 
KTVKNGLILQSISNDVYQNLAVEDWIHDHMNLEGKPILFFWQNSPSVVIGRHQNPWQECNLNLMREEGIKLARRRSGGGTVYHDMGNINLTFFTTKKKYD
RMENLKLIVRALNAVQPQLDVQATKRFDLLLDGQFKISGTASKIGRTTAYHHCTLLCSTDGTFLSSLLKSPYQGIRSNATASIPSLVKNLLEKDPTLTCE
VLMNAVATEYAAYHQIDNHIHLINPTDETLFPGINSKAKELQTWEWIYGKTPKFSINTSFHVLYEQSHLEIKVFIDIKNGRIEICNIEAPDHWLPLEIRD
KLNSSLIGSKFCPTETTMLTNILLRTCPQDHKLNSKWNILCEKIKGIM

transit_peptide: 1..25
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q9Y234.1)
calculated_mol_wt: 2804
peptide sequence: 
MLIPFSMKNCFQLLCNCQVPAAGFK

mat_peptide: 26..373
product: Lipoyltransferase 1, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q9Y234.1)
calculated_mol_wt: 39693
peptide sequence: 
KTVKNGLILQSISNDVYQNLAVEDWIHDHMNLEGKPILFFWQNSPSVVIGRHQNPWQECNLNLMREEGIKLARRRSGGGTVYHDMGNINLTFFTTKKKYD
RMENLKLIVRALNAVQPQLDVQATKRFDLLLDGQFKISGTASKIGRTTAYHHCTLLCSTDGTFLSSLLKSPYQGIRSNATASIPSLVKNLLEKDPTLTCE
VLMNAVATEYAAYHQIDNHIHLINPTDETLFPGINSKAKELQTWEWIYGKTPKFSINTSFHVLYEQSHLEIKVFIDIKNGRIEICNIEAPDHWLPLEIRD
KLNSSLIGSKFCPTETTMLTNILLRTCPQDHKLNSKWNILCEKIKGIM

transit_peptide: 1..25
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q9Y234.1)
calculated_mol_wt: 2804
peptide sequence: 
MLIPFSMKNCFQLLCNCQVPAAGFK

mat_peptide: 26..373
product: Lipoyltransferase 1, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q9Y234.1)
calculated_mol_wt: 39693
peptide sequence: 
KTVKNGLILQSISNDVYQNLAVEDWIHDHMNLEGKPILFFWQNSPSVVIGRHQNPWQECNLNLMREEGIKLARRRSGGGTVYHDMGNINLTFFTTKKKYD
RMENLKLIVRALNAVQPQLDVQATKRFDLLLDGQFKISGTASKIGRTTAYHHCTLLCSTDGTFLSSLLKSPYQGIRSNATASIPSLVKNLLEKDPTLTCE
VLMNAVATEYAAYHQIDNHIHLINPTDETLFPGINSKAKELQTWEWIYGKTPKFSINTSFHVLYEQSHLEIKVFIDIKNGRIEICNIEAPDHWLPLEIRD
KLNSSLIGSKFCPTETTMLTNILLRTCPQDHKLNSKWNILCEKIKGIM

transit_peptide: 1..25
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q9Y234.1)
calculated_mol_wt: 2804
peptide sequence: 
MLIPFSMKNCFQLLCNCQVPAAGFK

mat_peptide: 26..373
product: Lipoyltransferase 1, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q9Y234.1)
calculated_mol_wt: 39693
peptide sequence: 
KTVKNGLILQSISNDVYQNLAVEDWIHDHMNLEGKPILFFWQNSPSVVIGRHQNPWQECNLNLMREEGIKLARRRSGGGTVYHDMGNINLTFFTTKKKYD
RMENLKLIVRALNAVQPQLDVQATKRFDLLLDGQFKISGTASKIGRTTAYHHCTLLCSTDGTFLSSLLKSPYQGIRSNATASIPSLVKNLLEKDPTLTCE
VLMNAVATEYAAYHQIDNHIHLINPTDETLFPGINSKAKELQTWEWIYGKTPKFSINTSFHVLYEQSHLEIKVFIDIKNGRIEICNIEAPDHWLPLEIRD
KLNSSLIGSKFCPTETTMLTNILLRTCPQDHKLNSKWNILCEKIKGIM

transit_peptide: 1..25
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q9Y234.1)
calculated_mol_wt: 2804
peptide sequence: 
MLIPFSMKNCFQLLCNCQVPAAGFK

mat_peptide: 26..373
product: Lipoyltransferase 1, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q9Y234.1)
calculated_mol_wt: 39693
peptide sequence: 
KTVKNGLILQSISNDVYQNLAVEDWIHDHMNLEGKPILFFWQNSPSVVIGRHQNPWQECNLNLMREEGIKLARRRSGGGTVYHDMGNINLTFFTTKKKYD
RMENLKLIVRALNAVQPQLDVQATKRFDLLLDGQFKISGTASKIGRTTAYHHCTLLCSTDGTFLSSLLKSPYQGIRSNATASIPSLVKNLLEKDPTLTCE
VLMNAVATEYAAYHQIDNHIHLINPTDETLFPGINSKAKELQTWEWIYGKTPKFSINTSFHVLYEQSHLEIKVFIDIKNGRIEICNIEAPDHWLPLEIRD
KLNSSLIGSKFCPTETTMLTNILLRTCPQDHKLNSKWNILCEKIKGIM