LMPD Database

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LMP006621

UniProt Annotations

Entry Information
Gene Nameinositol monophosphatase domain containing 1
Protein EntryIMPA3_HUMAN
UniProt IDQ9NX62
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityAdenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate.
Catalytic ActivityMyo-inositol phosphate + H(2)O = myo-inositol + phosphate.
CofactorName=Mg(2+); Xref=ChEBI
DiseaseChondrodysplasia with joint dislocations, GPAPP type (CDP-GPAPP) [MIM
Enzyme RegulationStrongly inhibited by lithium.
FunctionMay play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation.
PathwayPolyol metabolism; myo-inositol biosynthesis; myo- inositol from D-glucose 6-phosphate: step 2/2.
PtmContains N-linked glycan resistant to endoglycosydase H.
SimilarityBelongs to the inositol monophosphatase family.
Subcellular LocationGolgi apparatus, trans-Golgi network membrane ; Single-pass type II membrane protein .