LMPD Database

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LMP006610

UniProt Annotations

Entry Information
Gene Nameoxysterol binding protein
Protein EntryOSBP1_MOUSE
UniProt IDQ3B7Z2
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3B7Z2-1; Sequence=Displayed; Name=2; IsoId=Q3B7Z2-2; Sequence=VSP_035281, VSP_035282; Note=No experimental confirmation available.;
DomainThe PH domain control cholesterol binding without affecting 25-hydroxycholesterol binding. {ECO:0000250}.
DomainThe second coiled-coil domain is required for interaction with the tyrosine phosphatase. {ECO:0000250}.
FunctionBinds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25- hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAI07328.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAI07329.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
SimilarityBelongs to the OSBP family. {ECO:0000305}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular LocationCytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=When bound to oxysterols, translocates to the periphery of Golgi membranes. {ECO:0000250}.
SubunitHomodimer or homotrimer. Interacts with VAPA (By similarity). {ECO:0000250}.