LMPD Database

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LMP006528

UniProt Annotations

Entry Information
Gene Namealdo-keto reductase family 1, member E2
Protein EntryAKCL2_HUMAN
UniProt IDQ96JD6
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q96JD6-1; Sequence=Displayed; Name=2; Synonyms=HTSP2; IsoId=Q96JD6-2; Sequence=VSP_025615; Name=3; Synonyms=HTSP1; IsoId=Q96JD6-3; Sequence=VSP_025615, VSP_025616, VSP_025617; Name=4; Synonyms=HTSP4; IsoId=Q96JD6-4; Sequence=VSP_025616, VSP_025617; Name=5; Synonyms=HTSP3; IsoId=Q96JD6-5; Sequence=VSP_025614;
Biophysicochemical PropertiesKinetic parameters: KM=6.1 uM for 9,10-phenanthrenequinone with NADPH as cofactor ; Vmax=0.42 nmol/min/mg enzyme towards 9,10-phenanthrenequinone with NADPH as cofactor ;
Catalytic Activity1,5-anhydro-D-glucitol + NADP(+) = 1,5- anhydro-D-fructose + NADPH.
FunctionCatalyzes the NADPH-dependent reduction of 1,5-anhydro- D-fructose (AF) to 1,5-anhydro-D-glucitol. Can also catalyze the reduction of various aldehydes and quinones (By similarity). Has low NADPH-dependent reductase activity towards 9,10- phenanthrenequinone (in vitro).
SimilarityBelongs to the aldo/keto reductase family.
Subcellular LocationCytoplasm .
Tissue SpecificityTestis-specific.