LMPD Database

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LMP006519

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol glycan anchor biosynthesis, class X
Protein EntryPIGX_MOUSE
UniProt IDQ99LV7
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99LV7-1; Sequence=Displayed; Name=2; IsoId=Q99LV7-2; Sequence=VSP_019843; Note=No experimental confirmation available.;
FunctionEssential component of glycosylphosphatidylinositol- mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM (By similarity). {ECO:0000250}.
PathwayGlycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
PtmN-glycosylated. {ECO:0000250}.
Sequence CautionSequence=BAC25223.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};
SimilarityBelongs to the PIGX family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
SubunitInteracts with PIGM. {ECO:0000250}.