LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP006519

Record overview

LMPD IDLMP006519
Gene ID72084
SpeciesMus musculus(Mouse)
Gene Namephosphatidylinositol glycan anchor biosynthesis, class X
Gene SymbolPigx
Synonyms2010319C14Rik; PIG-X
Alternate namesphosphatidylinositol-glycan biosynthesis class X protein; phosphatidylinositol glycan, class X
Chromosome16
Map Location16 B2|16
SummaryThis gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Studies in rat indicate that the protein is translated from a non-AUG translation initiation site. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for Pigx

Proteins

phosphatidylinositol-glycan biosynthesis class X protein isoform 1 precursor
Refseq ID:NP_077784
Protein GI:161377435
UniProt ID:Q99LV7
mRNA ID:NM_024464
Length:254
RefSeq Status:REVIEWED
MAAGAVAWLLLWAAWLVGRLAADFSDAPFSAGKGVRATCSEIILRQEFLKDGFHRDLLIKVKFGESIEDLQTCRLLIKHYIPPGLFVDPYELASLRERNL
TEAVMLSESFNIEAPNYLSNESAVLIYARQDAQCIDCFQAFLPVHYRYHRPHKKDGDTLIVVNNPDLLMYCDQEFPILKCWAQSEVAAPCALKSEEICQW
KSMQYKSILKNLTVQVPVGLTIHTSLVCSVTLLITILCSTLILLAVFKYGHFSL
 
sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2311
peptide sequence: 
MAAGAVAWLLLWAAWLVGRLAA

mat_peptide: 23..252
product: phosphatidylinositol-glycan biosynthesis class X protein isoform 2
calculated_mol_wt: 26167
peptide sequence: 
DFSDAPFSAGVRATCSEIILRQEFLKDGFHRDLLIKVKFGESIEDLQTCRLLIKHYIPPGLFVDPYELASLRERNLTEAVMLSESFNIEAPNYLSNESAV
LIYARQDAQCIDCFQAFLPVHYRYHRPHKKDGDTLIVVNNPDLLMYCDQEFPILKCWAQSEVAAPCALKSEEICQWKSMQYKSILKNLTVQVPVGLTIHT
SLVCSVTLLITILCSTLILLAVFKYGHFSL

sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2311
peptide sequence: 
MAAGAVAWLLLWAAWLVGRLAA

mat_peptide: 23..254
product: phosphatidylinositol-glycan biosynthesis class X protein isoform 1
calculated_mol_wt: 26352
peptide sequence: 
DFSDAPFSAGKGVRATCSEIILRQEFLKDGFHRDLLIKVKFGESIEDLQTCRLLIKHYIPPGLFVDPYELASLRERNLTEAVMLSESFNIEAPNYLSNES
AVLIYARQDAQCIDCFQAFLPVHYRYHRPHKKDGDTLIVVNNPDLLMYCDQEFPILKCWAQSEVAAPCALKSEEICQWKSMQYKSILKNLTVQVPVGLTI
HTSLVCSVTLLITILCSTLILLAVFKYGHFSL