LMPD Database

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LMP005763

UniProt Annotations

Entry Information
Gene NameALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
Protein EntryALG1_HUMAN
UniProt IDQ9BT22
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BT22-1; Sequence=Displayed; Name=2; IsoId=Q9BT22-2; Sequence=VSP_056931; Note=No experimental confirmation available;
Catalytic ActivityGDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-1,4-D-mannosylchitobiosyldiphosphodolichol.
DiseaseCongenital disorder of glycosylation 1K (CDG1K) [MIM
FunctionParticipates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.
PathwayProtein modification; protein glycosylation.
Sequence CautionSequence=AAQ89432.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily.
Subcellular LocationEndoplasmic reticulum membrane {ECO
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ALG1";