LMPD Database

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LMP005684

UniProt Annotations

Entry Information
Gene Namejumonji domain containing 6
Protein EntryJMJD6_MOUSE
UniProt IDQ9ERI5
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ERI5-1; Sequence=Displayed; Name=2; IsoId=Q9ERI5-2; Sequence=VSP_014024, VSP_014025; Note=No experimental confirmation available.;
CautionWas initially thought to constitute the phosphatidylserine receptor, a receptor that mediates recognition of phosphatidylserine, a specific marker only present at the surface of apoptotic cells. Phosphatidylserine receptor probably participates in apoptotic cell phagocytosis. This protein was identified using phage display expressing mAb 217, an antibody that specifically recognizes phosphatidylserine receptor. However, its nuclear localization and the fact that mAb 217 antibody still recognizes the phosphatidylserine receptor in mice lacking Jmjd6, strongly suggest that it does not constitute the receptor for phosphatidylserine and is not involved in apoptotic cell removal. {ECO:0000305}.
CofactorName=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000250}; Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000250};
Developmental StageExpressed early in development. Expressed from embryonic stem cells and throughout embryogenesis. {ECO:0000269|PubMed:14645847, ECO:0000269|PubMed:15345036}.
Disruption PhenotypeMice display perinatal lethality, growth retardation, severe anemia and a delay in terminal differentiation of the kidney, intestine, liver and lungs during embryogenesis. Moreover, eye development can be severely disturbed, ranging from defects in retinal differentiation to complete unilateral or bilateral absence of eyes. According to PubMed:14645847, mice are defective in removing apoptotic cells, especially in the lung and brain, in which dead cells accumulate, causing abnormal development and leading to neonatal lethality. According to PubMed:14715629, mice lacking Jmjd6 display a reduced number of macrophages and apoptotic cells in fetal liver. In contrast, according to PubMed:15345036, mice show a normal engulfment of apoptotic cells. The contradictory results concerning apoptosis and macrophage function may be explained by the fact that the protein plays a key role in hematopoietic differentiation. {ECO:0000269|PubMed:14645847, ECO:0000269|PubMed:14715629, ECO:0000269|PubMed:15345036}.
DomainThe nuclear localization signal motifs are necessary and sufficient to target it into the nucleus. {ECO:0000250}.
FunctionDioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses (By similarity). {ECO:0000250}.
Sequence CautionSequence=BAC65599.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the JMJD6 family. {ECO:0000305}.
SimilarityContains 1 JmjC domain. {ECO:0000255|PROSITE- ProRule:PRU00538}.
Subcellular LocationNucleus, nucleoplasm {ECO:0000269|PubMed:14729065}. Nucleus, nucleolus {ECO:0000250}. Note=Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle (By similarity). {ECO:0000250}.
SubunitInteracts with LUC7L2 and LUC7L3. Interacts with BRD4 (By similarity). Interacts with U2AF2/U2AF65. {ECO:0000250, ECO:0000269|PubMed:21300889}.
Tissue SpecificityWidely expressed. Expressed in brain, eye, spinal chord, thymus, lung, liver, kidney and intestine. {ECO:0000269|PubMed:14645847, ECO:0000269|PubMed:15345036}.