LMPD Database

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LMP005600

UniProt Annotations

Entry Information
Gene Namecubilin (intrinsic factor-cobalamin receptor)
Protein EntryCUBN_HUMAN
UniProt IDO60494
SpeciesHuman
Comments
Comment typeDescription
DiseaseRecessive hereditary megaloblastic anemia 1 (RH-MGA1) [MIM
DomainThe CUB domains 5 to 8 mediate binding to GIF and ALB. CUB domains 1 and 2 mediate interaction with LRP2.
FunctionCotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. {ECO
PtmN-glycosylated. {ECO
PtmThe precursor is cleaved by a trans-Golgi proteinase furin. The result is a propeptide cleaved off.
SimilarityContains 27 CUB domains. {ECO
SimilarityContains 7 EGF-like domains. {ECO
Subcellular LocationEndosome membrane ; Peripheral membrane protein {ECO
SubunitInteracts with LRP2 in a dual-receptor complex in a calcium-dependent manner. Component of the cubam complex composed of CUBN and AMN. The cubam complex can oligomerize and form cubam trimers. Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with LRP1 and PID1/PCLI1. {ECO
Tissue SpecificityExpressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney.