LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP005573

UniProt Annotations

Entry Information
Gene NameATP-binding cassette, sub-family B (MDR/TAP), member 11
Protein EntryABCBB_MOUSE
UniProt IDQ9QY30
SpeciesMouse
Comments
Comment typeDescription
DomainMultifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.
FunctionInvolved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
SimilarityBelongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. {ECO:0000305}.
SimilarityContains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule:PRU00441}.
SimilarityContains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule:PRU00434}.
Subcellular LocationMembrane; Multi-pass membrane protein.
SubunitInteracts with HAX1. {ECO:0000250}.
Tissue SpecificityExpressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.