LMPD Database

LMP005573

Record overview

LMPD ID	LMP005573
Gene ID	27413
Species	Mus musculus(Mouse)
Gene Name	ATP-binding cassette, sub-family B (MDR/TAP), member 11
Gene Symbol	Abcb11
Synonyms	ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP
Alternate names	bile salt export pump; sister of P-glycoprotein; ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B, member 11
Chromosome	2
Map Location	2 C2\|2 39.69 cM
Summary	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt transporter in humans and mice. Mutations in the human gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for Abcb11

Proteins

bile salt export pump

Refseq ID:	NP_066302
Protein GI:	120432047
UniProt ID:	Q9QY30
mRNA ID:	NM_021022
Length:	1321
RefSeq Status:	REVIEWED

MSDSVILRSVKKFGEENHAFESDGFHNNDKKSRLQDKKKGEGARVGFFELFRFSSSKDNWLMFMGSVCALLHGMAQPGMIIVFGILTDIFVEYDIERQEL
SIPEKVCMNNTIVWINSSFNQNMTNGTSCGLVDINSEVIKFSGIYAGVGVAVLILGYFQIRLWVITGARQIRKMRKFYFRRIMRMEIGWFDCTSVGELNS
RFSDDINKIDEAIADQMALFLQRLSTALSGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSVAKFTELELKAYAKAGSIADEVLSSIRTVAAFGGENKE
VERYEKNLMFAQRWGIWKGMVMGFFTGYMWCLIFFCYALAFWYGSRLVLDEGEYTPGTLIQIFLCVIIAAMNIGNASSCLEIFSTGCSAASSIFQTIDRQ
PVMDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGETTAFVGSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGI
VEQEPVLFSTTIAENIRLGREEATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRKPKILLLDMATSALDNESEAKVQGA
LNKIQHGHTIISVAHRLSTVRSADVIIGFEHGTAVERGTHEELLERKGVYFMLVTLQSQEDNTHKETGIKGKDTTEGDTPERTFSRGSYQDSLRASIRQR
SKSQLSHLSHEPPLAIGDHKSSYEDRKDNDVLVEEVEPAPVRRILKYNISEWPYILVGALCAAINGAVTPIYSLLFSQILKTFSLVDKEQQRSEIYSMCL
FFVILGCVSLFTQFLQGYNFAKSGELLTKRLRKFGFKAMLRQDIGWFDDLKNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIFVAVLIAFLFNWKL
SLVISVFFPFLALSGAVQTKMLTGFASQDKEILEKAGQITNEALSNIRTVAGIGVEGRFIKAFEVELEKSYKTAIRKANVYGLCYAFSQGISFLANSAAY
RYGGYLIVYEDLNFSYVFRVVSSIAMSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPIDVYSGAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLS
VSVDPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDF
VMSLPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQLALDKAREGRTCIVIAHRLSTIQNSDIIAVMSQGVVIEKGTH
KKLMDQKGAYYKLVITGAPIS