LMPD Database

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LMP005499

UniProt Annotations

Entry Information
Gene Nameangiogenin, ribonuclease, RNase A family, 5
Protein EntryANGI_HUMAN
UniProt IDP03950
SpeciesHuman
Comments
Comment typeDescription
CautionIt is uncertain whether Met-1 or Met-3 is the initiator.
Developmental StageLow level expression in the developing fetus, increased in the neonate, and maximal in the adult.
DiseaseAmyotrophic lateral sclerosis 9 (ALS9) [MIM
FunctionBinds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. {ECO
InteractionP35609:ACTN2; NbExp=4; IntAct=EBI-525291, EBI-77797; P19883:FST; NbExp=3; IntAct=EBI-525291, EBI-1571188; P13489:RNH1; NbExp=2; IntAct=EBI-525291, EBI-1237106;
Sequence CautionSequence=AAH20704.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
SimilarityBelongs to the pancreatic ribonuclease family.
Subcellular LocationSecreted, extracellular space, extracellular matrix, basement membrane. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA.
SubunitInteracts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur. {ECO
Tissue SpecificityExpressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ANGID635ch14q11.html";
Web ResourceName=Functional Glycomics Gateway - Glycan Binding; Note=Angiogenin; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_other_803";
Web ResourceName=R&D Systems' cytokine mini-reviews: Angiogenin; URL="http://www.rndsystems.com/molecule_detail.aspx?m=1054";