LMPD Database

LMP005499

Record overview

LMPD ID	LMP005499
Gene ID	283
Species	Homo sapiens (Human)
Gene Name	angiogenin, ribonuclease, RNase A family, 5
Gene Symbol	ANG
Synonyms	ALS9; HEL168; RAA1; RNASE4; RNASE5
Alternate names	angiogenin; RNase 5; ribonuclease 5; ribonuclease A A1; epididymis luminal protein 168
Chromosome	14
Map Location	14q11.1-q11.2
EC Number	3.1.27.-
Summary	The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2014]
Orthologs	View orthologs and multiple alignments for ANG

Proteins

angiogenin precursor

Refseq ID:	NP_001091046
Protein GI:	148277046
UniProt ID:	P03950
mRNA ID:	NM_001097577
Length:	147
RefSeq Status:	REVIEWED

angiogenin precursor
`MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSF QVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP`

Refseq ID:	NP_001136
Protein GI:	4557313
UniProt ID:	P03950
mRNA ID:	NM_001145
Length:	147
RefSeq Status:	REVIEWED

Protein sequence is identical to GI:148277046 (mRNA isoform)

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2425
peptide sequence: 
MVMGLGVLLLVFVLGLGLTPPTLA

mat_peptide: 25..147
product: angiogenin
experiment: DESCRIPTION:antimicrobial peptide[PMID: 12548285]
calculated_mol_wt: 14143
peptide sequence: 
QDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGF
RNVVVACENGLPVHLDQSIFRRP

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2425
peptide sequence: 
MVMGLGVLLLVFVLGLGLTPPTLA

mat_peptide: 25..147
product: angiogenin
experiment: DESCRIPTION:antimicrobial peptide[PMID: 12548285]
calculated_mol_wt: 14143
peptide sequence: 
QDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGF
RNVVVACENGLPVHLDQSIFRRP