LMPD Database

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LMP005381

UniProt Annotations

Entry Information
Gene Namecarbohydrate (chondroitin 4) sulfotransferase 12
Protein EntryCHSTC_HUMAN
UniProt IDQ9NRB3
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate.
FunctionCatalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.
InteractionQ9NYU2:UGGT1; NbExp=1; IntAct=EBI-1042837, EBI-1056389;
SimilarityBelongs to the sulfotransferase 2 family.
Subcellular LocationGolgi apparatus membrane ; Single-pass type II membrane protein .
Tissue SpecificityWidely expressed. Expressed a high level in spinal chord, heart, spleen, thyroid, pituitary gland, adrenal gland, peripheral blood leukocytes, thymus, lung, small intestine, fetal kidney, fetal spleen and fetal lung.