LMPD Database

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LMP004978

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol glycan anchor biosynthesis, class X
Protein EntryPIGX_HUMAN
UniProt IDQ8TBF5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TBF5-1; Sequence=Displayed; Name=2; IsoId=Q8TBF5-2; Sequence=VSP_019842; Note=No experimental confirmation available.;
FunctionEssential component of glycosylphosphatidylinositol- mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM (By similarity).
PathwayGlycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
PtmN-glycosylated.
Sequence CautionSequence=AAH22542.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=AAH22542.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence= ; Sequence=BAA91233.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAA91233.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence= ; Sequence=BAA91233.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence= ;
SimilarityBelongs to the PIGX family.
Subcellular LocationEndoplasmic reticulum membrane {ECO
SubunitInteracts with PIGM.