LMPD Database

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LMP004978

Record overview

LMPD IDLMP004978
Gene ID54965
SpeciesHomo sapiens (Human)
Gene Namephosphatidylinositol glycan anchor biosynthesis, class X
Gene SymbolPIGX
SynonymsPIG-X
Alternate namesphosphatidylinositol-glycan biosynthesis class X protein; GPI-mannosyltransferase subunit
Chromosome3
Map Location3q29
SummaryThis gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Studies in rat indicate that the protein is translated from a non-AUG translation initiation site. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
OrthologsView orthologs and multiple alignments for PIGX

Proteins

phosphatidylinositol-glycan biosynthesis class X protein isoform 1 precursor
Refseq ID:NP_001159776
Protein GI:261490708
UniProt ID:Q8TBF5
mRNA ID:NM_001166304
Length:276
RefSeq Status:REVIEWED
MAARVAAVRAAAWLLLGAATGLTRGPAAAFTAARSDAGIRAMCSEIILRQEVLKDGFHRDLLIKVKFGESIEDLHTCRLLIKQDIPAGLYVDPYELASLR
ERNITEAVMVSENFDIEAPNYLSKESEVLIYARRDSQCIDCFQAFLPVHCRYHRPHSEDGEASIVVNNPDLLMFCDQAGSRRMIRFRFDSFDKTIEFPIL
KCWAHSEVAAPCALENEDICQWNKMKYKSVYKNVILQVPVGLTVHTSLVCSVTLLITILCSTLILVAVFKYGHFSL
 
phosphatidylinositol-glycan biosynthesis class X protein isoform 2 precursor
Refseq ID:NP_060331
Protein GI:261490706
UniProt ID:Q8TBF5
mRNA ID:NM_017861
Length:258
RefSeq Status:REVIEWED
MAARVAAVRAAAWLLLGAATGLTRGPAAAFTAARSDAGIRAMCSEIILRQEVLKDGFHRDLLIKVKFGESIEDLHTCRLLIKQDIPAGLYVDPYELASLR
ERNITEAVMVSENFDIEAPNYLSKESEVLIYARRDSQCIDCFQAFLPVHCRYHRPHSEDGEASIVVNNPDLLMFCDQEFPILKCWAHSEVAAPCALENED
ICQWNKMKYKSVYKNVILQVPVGLTVHTSLVCSVTLLITILCSTLILVAVFKYGHFSL
 
sig_peptide: 1..21
note: SignalP 3.0 Server prediction
calculated_mol_wt: 2040
peptide sequence: 
MAARVAAVRAAAWLLLGAATG

mat_peptide: 22..276
product: phosphatidylinositol-glycan biosynthesis class X protein isoform 1
calculated_mol_wt: 28952
peptide sequence: 
LTRGPAAAFTAARSDAGIRAMCSEIILRQEVLKDGFHRDLLIKVKFGESIEDLHTCRLLIKQDIPAGLYVDPYELASLRERNITEAVMVSENFDIEAPNY
LSKESEVLIYARRDSQCIDCFQAFLPVHCRYHRPHSEDGEASIVVNNPDLLMFCDQAGSRRMIRFRFDSFDKTIEFPILKCWAHSEVAAPCALENEDICQ
WNKMKYKSVYKNVILQVPVGLTVHTSLVCSVTLLITILCSTLILVAVFKYGHFSL

sig_peptide: 1..21
note: SignalP 3.0 Server prediction
calculated_mol_wt: 2040
peptide sequence: 
MAARVAAVRAAAWLLLGAATG

mat_peptide: 22..258
product: phosphatidylinositol-glycan biosynthesis class X protein isoform 2
calculated_mol_wt: 26766
peptide sequence: 
LTRGPAAAFTAARSDAGIRAMCSEIILRQEVLKDGFHRDLLIKVKFGESIEDLHTCRLLIKQDIPAGLYVDPYELASLRERNITEAVMVSENFDIEAPNY
LSKESEVLIYARRDSQCIDCFQAFLPVHCRYHRPHSEDGEASIVVNNPDLLMFCDQEFPILKCWAHSEVAAPCALENEDICQWNKMKYKSVYKNVILQVP
VGLTVHTSLVCSVTLLITILCSTLILVAVFKYGHFSL