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LMPD Database

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LMP004693

UniProt Annotations

Entry Information

Gene Name	isoprenylcysteine carboxyl methyltransferase
Protein Entry	ICMT_HUMAN
UniProt ID	O60725
Species	Human

Comments

Comment type	Description
Catalytic Activity	S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C- terminal S-farnesyl-L-cysteine methyl ester. {ECO
Cofactor	Name=Zn(2+); Xref=ChEBI
Function	Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
Similarity	Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
Subcellular Location	Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue Specificity	Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.