LMPD Database

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LMP004693

Record overview

LMPD IDLMP004693
Gene ID23463
SpeciesHomo sapiens (Human)
Gene Nameisoprenylcysteine carboxyl methyltransferase
Gene SymbolICMT
SynonymsHSTE14; MST098; MSTP098; PCCMT; PCMT; PPMT
Alternate namesprotein-S-isoprenylcysteine O-methyltransferase; prenylcysteine carboxyl methyltransferase; prenylated protein carboxyl methyltransferase; protein-S isoprenylcysteine O-methyltransferase
Chromosome1
Map Location1p36.21
EC Number2.1.1.100
SummaryThis gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for ICMT

Proteins

protein-S-isoprenylcysteine O-methyltransferase
Refseq ID:NP_036537
Protein GI:6912430
UniProt ID:O60725
mRNA ID:NM_012405
Length:284
RefSeq Status:REVIEWED
MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYRPPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSL
SLFHYSEYLVTAVNNPKSLSLDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFTAGSNFNHVVQNEKSDTHTLV
TSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTVWRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL