LMPD Database

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LMP004644

UniProt Annotations

Entry Information
Gene Nameacyl-CoA wax alcohol acyltransferase 2
Protein EntryAWAT2_HUMAN
UniProt IDQ6E213
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: Vmax=1232 pmol/min/mg enzyme with [14C]cetyl-CoA as substrate ;
Catalytic ActivityAcyl-CoA + a long-chain alcohol = CoA + a long-chain ester.
Catalytic ActivityAcyl-CoA + retinol = CoA + retinyl ester.
FunctionAcyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl- CoA
SimilarityBelongs to the diacylglycerol acyltransferase family.
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue SpecificityAbundant in tissues rich in sebaceous glands such as the preputial gland and eyelid. Highly expressed in skin, where it is primarily restricted to undifferentiated peripheral sebocytes. Also expressed at lower level in other tissues except pancreas. {ECO