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LMP004644

Record overview

LMPD IDLMP004644
Gene ID158835
SpeciesHomo sapiens (Human)
Gene Nameacyl-CoA wax alcohol acyltransferase 2
Gene SymbolAWAT2
SynonymsARAT; DC4; DGAT2L4; MFAT; WS
Alternate namesacyl-CoA wax alcohol acyltransferase 2; retinol O-fatty-acyltransferase; multifunctional O-acyltransferase; acyl-CoA retinol O-fatty-acyltransferase; diacylglycerol O-acyltransferase candidate 4; long-chain-alcohol O-fatty-acyltransferase 2; diacylglycerol O-acyltransferase 2-like protein 4
ChromosomeX
Map LocationXq13.1
EC Number2.3.1.75
SummaryThis gene encodes an enzyme belonging to the diacylglycerol acyltransferase family. This enzyme produces wax esters by the esterification of long chain (or wax) alcohols with acyl-CoA-derived fatty acids. It functions in lipid metabolism in the skin, mostly in undifferentiated peripheral sebocytes. This enzyme may also have acyl-CoA:retinol acyltransferase activities, where it catalyzes the synthesis of diacylglycerols and retinyl esters. [provided by RefSeq, May 2010]
OrthologsView orthologs and multiple alignments for AWAT2

Proteins

acyl-CoA wax alcohol acyltransferase 2
Refseq ID:NP_001002254
Protein GI:51317389
UniProt ID:Q6E213
mRNA ID:NM_001002254
Length:333
RefSeq Status:REVIEWED
MLLPSKKDLKTALDVFAVFQWSFSALLITTTVIAVNLYLVVFTPYWPVTVLILTWLAFDWKTPQRGGRRFTCVRHWRLWKHYSDYFPLKLLKTHDICPSR
NYILVCHPHGLFAHGWFGHFATEASGFSKIFPGITPYILTLGAFFWMPFLREYVMSTGACSVSRSSIDFLLTHKGTGNMVIVVIGGLAECRYSLPGSSTL
VLKNRSGFVRMALQHGVPLIPAYAFGETDLYDQHIFTPGGFVNRFQKWFQSMVHIYPCAFYGRGFTKNSWGLLPYSRPVTTIVGEPLPMPKIENPSQEIV
AKYHTLYIDALRKLFDQHKTKFGISETQELEII