LMPD Database

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LMP003948

UniProt Annotations

Entry Information
Gene Namecrystallin, zeta (quinone reductase)
Protein EntryQOR_HUMAN
UniProt IDQ08257
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q08257-1; Sequence=Displayed; Name=2; IsoId=Q08257-2; Sequence=VSP_042927, VSP_042928; Note=No experimental confirmation available.; Name=3; IsoId=Q08257-3; Sequence=VSP_046425; Note=No experimental confirmation available.;
Catalytic ActivityNADPH + 2 quinone = NADP(+) + 2 semiquinone.
FunctionDoes not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.
SimilarityBelongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Subcellular LocationCytoplasm .
SubunitHomotetramer. {ECO
Tissue SpecificityOnly very low amounts in the lens.