LMPD Database

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LMP003948

Record overview

LMPD IDLMP003948
Gene ID1429
SpeciesHomo sapiens (Human)
Gene Namecrystallin, zeta (quinone reductase)
Gene SymbolCRYZ
Synonyms-
Alternate namesquinone oxidoreductase; NADPH:quinone reductase
Chromosome1
Map Location1p31.1
EC Number1.6.5.5
SummaryCrystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. [provided by RefSeq, Sep 2008]
OrthologsView orthologs and multiple alignments for CRYZ

Proteins

quinone oxidoreductase isoform a
Refseq ID:NP_001880
Protein GI:13236495
UniProt ID:Q08257
mRNA ID:NM_001889
Length:329
RefSeq Status:REVIEWED
MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTIS
GGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNH
REVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIG
SQYPLEKVAEAHENIIHGSGATGKMILLL
 
quinone oxidoreductase isoform a
Refseq ID:NP_001123514
Protein GI:194239674
UniProt ID:Q08257
mRNA ID:NM_001130042
Length:329
RefSeq Status:REVIEWED
Protein sequence is identical to GI:13236495 (mRNA isoform)
 
quinone oxidoreductase isoform b
Refseq ID:NP_001123515
Protein GI:194239674
UniProt ID:Q08257
mRNA ID:NM_001130043
Length:329
RefSeq Status:REVIEWED
Protein sequence is identical to GI:13236495 (mRNA isoform)
 
quinone oxidoreductase isoform c
Refseq ID:NP_001128231
Protein GI:197927207
UniProt ID:Q08257
mRNA ID:NM_001134759
Length:192
RefSeq Status:REVIEWED
MHLLSSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLL
SHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILLL