LMPD Database

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LMP003796

UniProt Annotations

Entry Information
Gene NameG protein-coupled bile acid receptor 1
Protein EntryGPBAR_HUMAN
UniProt IDQ8TDU6
SpeciesHuman
Comments
Comment typeDescription
FunctionReceptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.
SimilarityBelongs to the G-protein coupled receptor 1 family.
Subcellular LocationCell membrane ; Multi-pass membrane protein .
Tissue SpecificityUbiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum. {ECO