LMPD Database

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LMP003796

Record overview

LMPD IDLMP003796
Gene ID151306
SpeciesHomo sapiens (Human)
Gene NameG protein-coupled bile acid receptor 1
Gene SymbolGPBAR1
SynonymsBG37; GPCR19; GPR131; M-BAR; TGR5
Alternate namesG-protein coupled bile acid receptor 1; hBG37; hGPCR19; membrane bile acid receptor; G-protein coupled receptor GPCR19; membrane-type receptor for bile acids; G-protein coupled bile acid receptor BG37
Chromosome2
Map Location2q35
SummaryThis gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for GPBAR1

Proteins

G-protein coupled bile acid receptor 1
Refseq ID:NP_001070662
Protein GI:116284382
UniProt ID:Q8TDU6
mRNA ID:NM_001077194
Length:330
RefSeq Status:REVIEWED
MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLL
ANLLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDIC
RLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQ
GLWGRASRDSPGPSIAYHPSSQSSVDLDLN
 
G-protein coupled bile acid receptor 1
Refseq ID:NP_001070659
Protein GI:116284384
UniProt ID:Q8TDU6
mRNA ID:NM_001077191
Length:330
RefSeq Status:REVIEWED
Protein sequence is identical to GI:116284382 (mRNA isoform)
 
G-protein coupled bile acid receptor 1
Refseq ID:NP_733800
Protein GI:24850109
UniProt ID:Q8TDU6
mRNA ID:NM_170699
Length:330
RefSeq Status:REVIEWED
Protein sequence is identical to GI:116284382 (mRNA isoform)