LMPD Database

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LMP003770

UniProt Annotations

Entry Information
Gene Nameparaoxonase 3
Protein EntryPON3_HUMAN
UniProt IDQ15166
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityAn aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol.
Catalytic ActivityAn N-acyl-L-homoserine lactone + H(2)O = an N- acyl-L-homoserine.
Catalytic ActivityA phenyl acetate + H(2)O = a phenol + acetate.
CofactorName=Ca(2+); Xref=ChEBI
FunctionHas low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
PtmThe signal sequence is not cleaved.
SimilarityBelongs to the paraoxonase family.
Subcellular LocationSecreted, extracellular space .
SubunitHomodimer.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/pon3/";