LMPD Database

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LMP003770

Record overview

LMPD IDLMP003770
Gene ID5446
SpeciesHomo sapiens (Human)
Gene Nameparaoxonase 3
Gene SymbolPON3
Synonyms-
Alternate namesserum paraoxonase/lactonase 3; paraoxanase-3; arylesterase 3
Chromosome7
Map Location7q21.3
EC Number3.1.1.2
SummaryThis gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PON3

Proteins

serum paraoxonase/lactonase 3
Refseq ID:NP_000931
Protein GI:29788996
UniProt ID:Q15166
mRNA ID:NM_000940
Length:354
RefSeq Status:REVIEWED
MGKLVALVLLGVGLSLVGEMFLAFRERVNASREVEPVEPENCHLIEELESGSEDIDILPSGLAFISSGLKYPGMPNFAPDEPGKIFLMDLNEQNPRAQAL
EISGGFDKELFNPHGISIFIDKDNTVYLYVVNHPHMKSTVEIFKFEEQQRSLVYLKTIKHELLKSVNDIVVLGPEQFYATRDHYFTNSLLSFFEMILDLR
WTYVLFYSPREVKVVAKGFCSANGITVSADQKYVYVADVAAKNIHIMEKHDNWDLTQLKVIQLGTLVDNLTVDPATGDILAGCHPNPMKLLNYNPEDPPG
SEVLRIQNVLSEKPRVSTVYANNGSVLQGTSVASVYHGKILIGTVFHKTLYCEL