LMPD Database

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LMP003630

UniProt Annotations

Entry Information
Gene Namesteroid receptor RNA activator 1
Protein EntryNONE_CAEEL
UniProt IDQ9HD15
SpeciesHuman
Comments
Comment typeDescription
FunctionFunctional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis. {ECO
InteractionQ92769:HDAC2; NbExp=2; IntAct=EBI-727136, EBI-301821;
MiscellaneousAppears to be the first example of a new class of functional RNAs also able to encode a protein.
Sequence CautionSequence=AAH40043.2; Type=Frameshift; Positions=29; Evidence= ;
SimilarityBelongs to the SRA1 family.
Subcellular LocationNucleus . Cytoplasm .
SubunitSRA1 RNA exists in a ribonucleoprotein complex containing NCOA1. The RNA also forms a complex with PUS1 and RARG in the nucleus. Interacts with AR. {ECO
Tissue SpecificityHighly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in both normal and tumorigenic breast epithelial cell lines. Significantly up- regulated in human tumors of the breast, ovary, and uterus. {ECO