LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP003587

UniProt Annotations

Entry Information
Gene Namecannabinoid receptor 1 (brain)
Protein EntryCNR1_HUMAN
UniProt IDP21554
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Long; IsoId=P21554-1; Sequence=Displayed; Name=2; Synonyms=CB1a, Short; IsoId=P21554-2; Sequence=VSP_001868; Note=Dubious isoform. A putative downstream initiation AUG is used to produce isoform 2 (PubMed:1718258). The use of the first AUG (same as isoform 1) gives a truncated protein of 36 AA. ; Name=3; Synonyms=CB1b; IsoId=P21554-3; Sequence=VSP_016529;
FunctionInvolved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.
PtmPalmitoylation at Cys-415 is important for recruitment at both plasma membrane and lipid rafts.
SimilarityBelongs to the G-protein coupled receptor 1 family.
Subcellular LocationCell membrane; Multi-pass membrane protein.
SubunitInteracts (via C-terminus) with CNRIP1.
Tissue SpecificityWidely expressed.