LMPD Database

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LMP003587

Record overview

LMPD IDLMP003587
Gene ID1268
SpeciesHomo sapiens (Human)
Gene Namecannabinoid receptor 1 (brain)
Gene SymbolCNR1
SynonymsCANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR
Alternate namescannabinoid receptor 1; central cannabinoid receptor
Chromosome6
Map Location6q14-q15
SummaryThis gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
OrthologsView orthologs and multiple alignments for CNR1

Proteins

cannabinoid receptor 1 isoform a
Refseq ID:NP_001153698
Protein GI:237681067
UniProt ID:P21554
mRNA ID:NM_001160226
Length:472
RefSeq Status:REVIEWED
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGE
NFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASF
TASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALR
SKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
 
cannabinoid receptor 1 isoform a
Refseq ID:NP_057167
Protein GI:38683844
UniProt ID:P21554
mRNA ID:NM_016083
Length:472
RefSeq Status:REVIEWED
Protein sequence is identical to GI:237681067 (mRNA isoform)
 
cannabinoid receptor 1 isoform a
Refseq ID:NP_001153730
Protein GI:237681173
UniProt ID:P21554
mRNA ID:NM_001160258
Length:472
RefSeq Status:REVIEWED
Protein sequence is identical to GI:237681067 (mRNA isoform)
 
cannabinoid receptor 1 isoform a
Refseq ID:NP_001153731
Protein GI:237681175
UniProt ID:P21554
mRNA ID:NM_001160259
Length:472
RefSeq Status:REVIEWED
Protein sequence is identical to GI:237681067 (mRNA isoform)
 
cannabinoid receptor 1 isoform b
Refseq ID:NP_149421
Protein GI:237681065
UniProt ID:P21554
mRNA ID:NM_033181
Length:439
RefSeq Status:REVIEWED
MKSILDGLADTTFRTITTDLLGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLE
NLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKA
VVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPD
QARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLH
KHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL