LMPD Database

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LMP003387

UniProt Annotations

Entry Information
Gene NameN-acylethanolamine acid amidase
Protein EntryNAAA_HUMAN
UniProt IDQ02083
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q02083-1; Sequence=Displayed; Name=2; IsoId=Q02083-2; Sequence=VSP_000330; Name=3; IsoId=Q02083-3; Sequence=VSP_000328, VSP_000329; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=97 uM for N-palmitoylethanolamine ; pH dependence: Optimum pH is 4.5 with N-palmitoylethanolamine as substrate. ;
Enzyme RegulationStimulated by DTT and Nonidet P-40.
FunctionDegrades bioactive fatty acid amides to their corresponding acids, with the following preference: N- palmitoylethanolamine > N-myristoylethanolamine > N- lauroylethanolamine = N-stearoylethanolamine > N- arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N- lauroylsphingosine and N-palmitoylsphingosine.
PtmAutoproteolytic cleavage in the acidic lumen of the lysosome activates the enzyme.
PtmN-glycosylated. Tunicamycin treatment causes a reduction in specific activity against N-palmitoylethanolamine. {ECO
SimilarityBelongs to the acid ceramidase family.
Subcellular LocationLysosome {ECO
SubunitHeterodimer of an alpha and a beta subunit, non- covalently linked.
Tissue SpecificityExpressed in numerous tissues, with highest levels in liver and kidney, followed by pancreas.