LMPD Database

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LMP003340

UniProt Annotations

Entry Information
Gene Namecannabinoid receptor 2 (macrophage)
Protein EntryCNR2_HUMAN
UniProt IDP34972
SpeciesHuman
Comments
Comment typeDescription
FunctionHeterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. {ECO
PtmConstitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.
SimilarityBelongs to the G-protein coupled receptor 1 family.
Subcellular LocationCell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO
Tissue SpecificityPreferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR