LMPD Database

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LMP003340

Record overview

LMPD IDLMP003340
Gene ID1269
SpeciesHomo sapiens (Human)
Gene Namecannabinoid receptor 2 (macrophage)
Gene SymbolCNR2
SynonymsCB-2; CB2; CX5
Alternate namescannabinoid receptor 2; testis-dominant CNR2 isoform CB2
Chromosome1
Map Location1p36.11
SummaryThe cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CNR2

Proteins

cannabinoid receptor 2
Refseq ID:NP_001832
Protein GI:4502929
UniProt ID:P34972
mRNA ID:NM_001841
Length:360
RefSeq Status:REVIEWED
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGV
DSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAF
LFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA
LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC