LMPD Database

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LMP003177

UniProt Annotations

Entry Information
Gene Nameceramide synthase 2
Protein EntryCERS2_HUMAN
UniProt IDQ96G23
SpeciesHuman
Comments
Comment typeDescription
FunctionSuppresses the growth of cancer cells. May be involved in sphingolipid synthesis.
InteractionP07306:ASGR1; NbExp=3; IntAct=EBI-1057080, EBI-1172335; P07307:ASGR2; NbExp=3; IntAct=EBI-1057080, EBI-1172636; P27449:ATP6V0C; NbExp=3; IntAct=EBI-1057080, EBI-721179; P07900:HSP90AA1; NbExp=2; IntAct=EBI-1057080, EBI-296047; O15245:SLC22A1; NbExp=3; IntAct=EBI-1057080, EBI-1172714;
Sequence CautionSequence=BAA91505.1; Type=Erroneous initiation; Evidence= ;
SimilarityContains 1 homeobox DNA-binding domain.
SimilarityContains 1 TLC (TRAM/LAG1/CLN8) domain.
Subcellular LocationNucleus membrane {ECO
SubunitInteracts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Interacts with ELOV1, HSD17B12 and TECR.
Tissue SpecificityExpressed in kidney, liver, brain, heart, placenta and lung.