LMPD Database

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LMP002835

UniProt Annotations

Entry Information
Gene Namegeranylgeranyl diphosphate synthase 1
Protein EntryGGPPS_HUMAN
UniProt IDO95749
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95749-1; Sequence=Displayed; Name=2; IsoId=O95749-2; Sequence=VSP_056578; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=3 uM for isopentenyl diphosphate ; KM=4.2 uM for farnesyl diphosphate ;
Catalytic Activity(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
Catalytic ActivityDimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
Catalytic ActivityGeranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.
CofactorName=Mg(2+); Xref=ChEBI
Enzyme RegulationSubject to product inhibition by geranylgeranyl diphosphate.
FunctionCatalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
PathwayIsoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
PathwayIsoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
PathwayIsoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.
SimilarityBelongs to the FPP/GGPP synthase family.
Subcellular LocationCytoplasm.
SubunitHomohexamer; trimer of homodimers.
Tissue SpecificityAbundantly expressed in testis. Found in other tissues to a lower extent.