LMPD Database

LMP002835

Record overview

LMPD IDLMP002835
Gene ID9453
SpeciesHomo sapiens (Human)
Gene Namegeranylgeranyl diphosphate synthase 1
Gene SymbolGGPS1
SynonymsGGPPS; GGPPS1
Alternate namesgeranylgeranyl pyrophosphate synthase; GGPPSase; GGPP synthase; geranyltranstransferase; farnesyltranstransferase; dimethylallyltranstransferase; farnesyl diphosphate synthase; (2E,6E)-farnesyl diphosphate synthase
Chromosome1
Map Location1q43
EC Number2.5.1.-
SummaryThis gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
OrthologsView orthologs and multiple alignments for GGPS1

Proteins

geranylgeranyl pyrophosphate synthase
Refseq ID:NP_001032354
Protein GI:83700220
UniProt ID:O95749
mRNA ID:NM_001037277
Length:300
RefSeq Status:REVIEWED
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGL
EKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSE
NKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE