LMPD Database

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LMP002781

UniProt Annotations

Entry Information
Gene Nameglutathione peroxidase 4
Protein EntryGPX41_MOUSE
UniProt IDO70325
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing, Alternative initiation; Named isoforms=3; Name=Mitochondrial; IsoId=O70325-1; Sequence=Displayed; Name=Nuclear; IsoId=Q91XR9-1; Sequence=External; Name=Cytoplasmic; IsoId=O70325-2; Sequence=VSP_018743; Note=Produced by alternative initiation at Met-28 of isoform Mitochondrial.;
Catalytic Activity2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H(2)O.
Disruption PhenotypeEmbryonic lethality. The embryos die after about 7.5 days of development. Causes neurodegeneration. Selective disruption of isoform mitochondrial causes sperm abnormalities and male infertility. {ECO:0000269|PubMed:18762024, ECO:0000269|PubMed:19417079}.
FunctionProtects cells against membrane lipid peroxidation and cell death. Isoform mitochondrial is required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. {ECO:0000269|PubMed:12566075, ECO:0000269|PubMed:18762024, ECO:0000269|PubMed:19417079}.
SimilarityBelongs to the glutathione peroxidase family. {ECO:0000305}.
Subcellular LocationMitochondrion. Cytoplasm.
SubunitMonomer. {ECO:0000250}.
Tissue SpecificityDetected in testis and sperm midpiece (at protein level). Present primarily in testis. {ECO:0000269|PubMed:19417079}.