LMPD Database

LMP002781

Record overview

LMPD IDLMP002781
Gene ID625249
SpeciesMus musculus(Mouse)
Gene Nameglutathione peroxidase 4
Gene SymbolGpx4
SynonymsGPx-4; GSHPx-4; PHGPx; mtPHGPx; snGPx
Alternate namesphospholipid hydroperoxide glutathione peroxidase, nuclear; sperm nuclei glutathione peroxidase; phospholipid hydroperoxide glutathione peroxidase, mitochondrial
Chromosome10
Map Location10 C1|10 39.72 cM
EC Number1.11.1.12
SummaryThis gene encodes a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. A similar protein in rat has been identified as a moonlighting protein based on its ability to serve dual functions as a peroxidase as well as a structural protein in mature spermatozoa. Disruption of this gene in spermatocytes is associated with male infertility. Alternative splicing results in multiple transcript variants. Two pseudogenes of this gene have been defined on chromosomes 10 and 17. [provided by RefSeq, Jan 2014]
OrthologsView orthologs and multiple alignments for Gpx4

Proteins

phospholipid hydroperoxide glutathione peroxidase, nuclear isoform 1
Refseq ID:NP_001032830
Protein GI:90903233
UniProt ID:O70325
mRNA ID:NM_001037741
Length:253
RefSeq Status:VALIDATED
MGRAAARKRGRCRQRGGSPRGRRRRGPGRQSPRKRPGPRRRKARARRRRRARPRRMEPIPEPFNPGPLLQEPPQYCNSSEFLGLCASRDDWRCARSMHEF
SAKDIDGHMVCLDKYRGFVCIVTNVASQUGKTDVNYTQLVDLHARYAECGLRILAFPCNQFGRQEPGSNQEIKEFAAGYNVKFDMYSKICVNGDDAHPLW
KWMKVQPKGRGMLGNAIKWNFTKFLIDKNGCVVKRYGPMEEPQVIEKDLPCYL
 
phospholipid hydroperoxide glutathione peroxidase, nuclear isoform 2 precursor
Refseq ID:NP_032188
Protein GI:90903235
UniProt ID:O70325
mRNA ID:NM_008162
Length:197
RefSeq Status:VALIDATED
MSWGRLSRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVCLDKYRGFVCIVTNVASQUGKTDVNYTQLVDLHARYAECGLRILAF
PCNQFGRQEPGSNQEIKEFAAGYNVKFDMYSKICVNGDDAHPLWKWMKVQPKGRGMLGNAIKWNFTKFLIDKNGCVVKRYGPMEEPQVIEKDLPCYL
 
sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2566
peptide sequence: 
MSWGRLSRLLKPALLCGALAAPGLA