LMPD Database

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LMP002716

UniProt Annotations

Entry Information
Gene Namesphingomyelin phosphodiesterase 1, acid lysosomal
Protein EntryASM_MOUSE
UniProt IDQ04519
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivitySphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
FunctionConverts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol.
MiscellaneousThere are two types of sphingomyelinases: ASM (acid), and NSM (neutral).
SimilarityBelongs to the acid sphingomyelinase family. {ECO:0000305}.
SimilarityContains 1 saposin B-type domain. {ECO:0000255|PROSITE-ProRule:PRU00415}.
Subcellular LocationLysosome.
SubunitMonomer.