LMPD Database

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LMP002714

UniProt Annotations

Entry Information
Gene Nameacyl-CoA thioesterase 8
Protein EntryACOT8_HUMAN
UniProt IDO14734
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityCholoyl-CoA + H(2)O = cholate + CoA.
FunctionAcyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA
InductionRegulated by peroxisome proliferator (such as Clofibrate), via the peroxisome proliferator-activated receptors (PPARs).
InteractionP04601:nef (xeno); NbExp=5; IntAct=EBI-1237371, EBI-6164028;
SimilarityBelongs to the C/M/P thioester hydrolase family.
Subcellular LocationPeroxisome.
SubunitInteracts with HIV-1 Nef.
Tissue SpecificityDetected in a T-cell line (at protein level). Ubiquitous.