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LMP002714

Record overview

LMPD IDLMP002714
Gene ID10005
SpeciesHomo sapiens (Human)
Gene Nameacyl-CoA thioesterase 8
Gene SymbolACOT8
SynonymsHNAACTE; PTE-1; PTE-2; PTE1; PTE2; hACTE-III; hTE
Alternate namesacyl-coenzyme A thioesterase 8; thioesterase II; thioesterase III; choloyl-CoA hydrolase; palmitoyl-CoA hydrolase; choloyl-coenzyme A thioesterase; long-chain fatty-acyl-CoA hydrolase; peroxisomal acyl-CoA thioesterase 1; HIV-Nef associated acyl-CoA thioesterase; peroxisomal long-chain acyl-CoA thioesterase 1; peroxisomal acyl-coenzyme A thioester hydrolase 1
Chromosome20
Map Location20q13.12
EC Number3.1.2.27
SummaryThe protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010]
OrthologsView orthologs and multiple alignments for ACOT8

Proteins

acyl-coenzyme A thioesterase 8
Refseq ID:NP_005460
Protein GI:34577075
UniProt ID:O14734
mRNA ID:NM_005469
Length:319
RefSeq Status:REVIEWED
MSSPQAPEDGQGCGDRGDPPGDLRSVLVTTVLNLEPLDEDLFRGRHYWVPAKRLFGGQIVGQALVAAAKSVSEDVHVHSLHCYFVRAGDPKLPVLYQVER
TRTGSSFSVRSVKAVQHGKPIFICQASFQQAQPSPMQHQFSMPTVPPPEELLDCETLIDQYLRDPNLQKRYPLALNRIAAQEVPIEIKPVNPSPLSQLQR
MEPKQMFWVRARGYIGEGDMKMHCCVAAYISDYAFLGTALLPHQWQHKVHFMVSLDHSMWFHAPFRADHWMLYECESPWAGGSRGLVHGRLWRQDGVLAV
TCAQEGVIRVKPQVSESKL