LMPD Database

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LMP002651

UniProt Annotations

Entry Information
Gene Namelow density lipoprotein receptor-related protein associated protein 1
Protein EntryAMRP_HUMAN
UniProt IDP30533
SpeciesHuman
Comments
Comment typeDescription
DiseaseMyopia 23, autosomal recessive (MYP23) [MIM
DiseaseNote=In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.
FunctionInteracts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.
InteractionP98155:VLDLR; NbExp=4; IntAct=EBI-715927, EBI-9004309;
PtmN-glycosylated. {ECO
SimilarityBelongs to the alpha-2-MRAP family.
Subcellular LocationEndoplasmic reticulum. Cytoplasm. Cell surface. Note=Intracellular and associated with cell surface receptors. Found in the endoplasmic reticulum.
SubunitPresent on cell surface forming a complex with the alpha- 2-macroglobulin receptor heavy and light chains. Binds LRP1B; binding is followed by internalization and degradation.