LMPD Database

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LMP002651

Record overview

LMPD IDLMP002651
Gene ID4043
SpeciesHomo sapiens (Human)
Gene Namelow density lipoprotein receptor-related protein associated protein 1
Gene SymbolLRPAP1
SynonymsA2MRAP; A2RAP; HBP44; MRAP; MYP23; RAP; alpha-2-MRAP
Alternate namesalpha-2-macroglobulin receptor-associated protein; 39 kDa receptor-associated protein; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)
Chromosome4
Map Location4p16.3
SummaryThis gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
OrthologsView orthologs and multiple alignments for LRPAP1

Proteins

alpha-2-macroglobulin receptor-associated protein precursor
Refseq ID:NP_002328
Protein GI:4505021
UniProt ID:P30533
mRNA ID:NM_002337
Length:357
RefSeq Status:REVIEWED
MAPRRVRSFLRGLPALLLLLLFLGPWPAASHGGKYSREKNQPKPSPKRESGEEFRMEKLNQLWEKAQRLHLPPVRLAELHADLKIQERDELAWKKLKLDG
LDEDGEKEARLIRNLNVILAKYGLDGKKDARQVTSNSLSGTQEDGLDDPRLEKLWHKAKTSGKFSGEELDKLWREFLHHKEKVHEYNVLLETLSRTEEIH
ENVISPSDLSDIKGSVLHSRHTELKEKLRSINQGLDRLRRVSHQGYSTEAEFEEPRVIDLWDLAQSANLTDKELEAFREELKHFEAKIEKHNHYQKQLEI
AHEKLRHAESVGDGERVSRSREKHALLEGRTKELGYTVKKHLQDLSGRISRARHNEL
 
sig_peptide: 1..30
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3333
peptide sequence: 
MAPRRVRSFLRGLPALLLLLLFLGPWPAAS