LMPD Database

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LMP002632

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 17, subfamily A, polypeptide 1
Protein EntryCP17A_HUMAN
UniProt IDP05093
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity17-alpha-hydroxyprogesterone = androst-4-ene- 3,17-dione + acetaldehyde.
Catalytic ActivityA C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O(2) = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H(2)O.
CofactorName=heme; Xref=ChEBI
DiseaseAdrenal hyperplasia 5 (AH5) [MIM
Enzyme RegulationRegulated predominantly by intracellular cAMP levels.
FunctionConversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.
PathwayLipid metabolism; steroid biosynthesis.
PtmPhosphorylation is necessary for 17,20-lyase, but not for 17- alpha-hydroxylase activity.
SimilarityBelongs to the cytochrome P450 family.
Subcellular LocationMembrane .
Web ResourceName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=CYP17A1";