LMPD Database

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LMP002578

UniProt Annotations

Entry Information
Gene Namefarnesyltransferase, CAAX box, alpha
Protein EntryFNTA_HUMAN
UniProt IDP49354
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P49354-1; Sequence=Displayed; Name=2; IsoId=P49354-2; Sequence=VSP_036468;
Catalytic ActivityFarnesyl diphosphate + protein-cysteine = S- farnesyl protein + diphosphate.
Catalytic ActivityGeranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
Enzyme RegulationActivated by the AGRIN-induced phosphorylation which is mediated by MUSK.
FunctionEssential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. {ECO
InteractionP49356:FNTB; NbExp=7; IntAct=EBI-602336, EBI-602349;
PtmPhosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA (By similarity).
SimilarityBelongs to the protein prenyltransferase subunit alpha family.
SimilarityContains 5 PFTA repeats. {ECO
SubunitInteracts with MUSK; the interaction is direct and mediates AGRIN-induced phosphorylation of FNTA (By similarity). Heterodimer of FNTA and FNTB (farnesyltransferase). Heterodimer of FNTA and PGGT1B (geranylgeranyltransferase). {ECO