LMPD Database

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LMP002578

Record overview

LMPD IDLMP002578
Gene ID2339
SpeciesHomo sapiens (Human)
Gene Namefarnesyltransferase, CAAX box, alpha
Gene SymbolFNTA
SynonymsFPTA; PGGT1A; PTAR2
Alternate namesprotein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; FTase-alpha; GGTase-I-alpha; farnesyl-protein transferase alpha-subunit; ras proteins prenyltransferase subunit alpha; type I protein geranyl-geranyltransferase alpha subunit; protein prenyltransferase alpha subunit repeat containing 2
Chromosome8
Map Location8p11
EC Number2.5.1.58
SummaryPrenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]
OrthologsView orthologs and multiple alignments for FNTA

Proteins

protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Refseq ID:NP_002018
Protein GI:4503771
UniProt ID:P49354
mRNA ID:NM_002027
Length:379
RefSeq Status:REVIEWED
MAATEGVGEAAQGGEPGQPAQPPPQPHPPPPQQQHKEEMAAEAGEAVASPMDDGFVSLDSPSYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSDKFRDVY
DYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLRDPSQELEFIADILNQDAKNY
HAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLL
DLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSTENDSPTNVQQ