LMPD Database


UniProt Annotations

Entry Information
Gene Namesolute carrier family 27 (fatty acid transporter), member 5
Protein EntryS27A5_HUMAN
UniProt IDQ9Y2P5
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y2P5-1; Sequence=Displayed; Name=2; IsoId=Q9Y2P5-2; Sequence=VSP_055810; Note=No experimental confirmation available.;
Catalytic ActivityATP + (25R)-3-alpha,7-alpha,12-alpha- trihydroxy-5-beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA.
Catalytic ActivityATP + cholate + CoA = AMP + diphosphate + choloyl-CoA.
FunctionAcyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. {ECO
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family.
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue SpecificityPredominantly expressed in liver.