LMPD Database

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LMP002290

UniProt Annotations

Entry Information
Gene Namepyruvate dehydrogenase kinase, isoenzyme 1
Protein EntryPDK1_MOUSE
UniProt IDQ8BFP9
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityATP + [pyruvate dehydrogenase (acetyl- transferring)] = ADP + [pyruvate dehydrogenase (acetyl- transferring)] phosphate.
FunctionKinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress (By similarity). {ECO:0000250}.
InductionUp-regulated by glucose and palmitate. Up- regulated via the HIF1A signaling pathway in response to hypoxia. {ECO:0000269|PubMed:16517406, ECO:0000269|PubMed:16631612}.
PtmPhosphorylated by constitutively activated ABL1, FGFR1, FLT3 and JAK2 (in vitro), and this may also occur in cancer cells that express constitutively activated ABL1, FGFR1, FLT3 and JAK2. Phosphorylation at Tyr-241 and Tyr-242 strongly increases kinase activity, while phosphorylation at Tyr-136 has a lesser effect (By similarity). {ECO:0000250}.
SimilarityBelongs to the PDK/BCKDK protein kinase family. {ECO:0000305}.
SimilarityContains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00107}.
Subcellular LocationMitochondrion matrix {ECO:0000250}.
SubunitHomodimer, and heterodimer with PDK2. Interacts with the pyruvate dehydrogenase complex subunit DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3) (By similarity). {ECO:0000250}.