LMPD Database

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LMP002080

UniProt Annotations

Entry Information
Gene Nameacyl-Coenzyme A dehydrogenase, long-chain
Protein EntryACADL_MOUSE
UniProt IDP51174
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityLong-chain-acyl-CoA + electron-transfer flavoprotein = long-chain-2,3-dehydroacyl-CoA + reduced electron- transfer flavoprotein.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692;
MiscellaneousA number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.
PathwayLipid metabolism; mitochondrial fatty acid beta- oxidation.
PtmAcetylation at Lys-318 and Lys-322 in proximity of the cofactor-binding sites strongly reduces catalytic activity. These sites are deacetylated by SIRT3. {ECO:0000269|PubMed:23576753, ECO:0000269|PubMed:24121500}.
SimilarityBelongs to the acyl-CoA dehydrogenase family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix.
SubunitHomotetramer.