LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP002080

Record overview

LMPD IDLMP002080
Gene ID11363
SpeciesMus musculus(Mouse)
Gene Nameacyl-Coenzyme A dehydrogenase, long-chain
Gene SymbolAcadl
SynonymsAA960361; AU018452; C79855; LCAD
Alternate nameslong-chain specific acyl-CoA dehydrogenase, mitochondrial; acetyl-Coenzyme A dehydrogenase, long-chain
Chromosome1
Map Location1 C3|1 33.64 cM
EC Number1.3.8.8
SummaryThis gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C12- and C16-acylCoA. In mice, deficiency of this gene can cause sudden death, cardiomyopathy as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012]
OrthologsView orthologs and multiple alignments for Acadl

Proteins

long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor
Refseq ID:NP_031407
Protein GI:31982520
UniProt ID:P51174
mRNA ID:NM_007381
Length:430
RefSeq Status:REVIEWED
MAARLLLRSLRVLSARSAPRPLPSARCSHSGAEARLETPSAKKLTDIGIRRIFSSEHDIFRESVRKFFQEEVIPHHTEWEKAGEVSREVWEKAGKQGLLG
INIAEKHGGIGGDLLSTAVTWEEQAYSNCTGPGFSLHSDIVMPYIANYGTKEQIEKFIPQMTAGKCIGAIAMTEPGAGSDLQGVRTNAKRSGSDWILNGS
KVFITNGWLSDLVIVVAVTNREARSPAHGISLFLVENGMKGFIKGRKLHKMGMKAQDTAELFFEDVRLPANALLGEENKGFYYLMQELPQERLLIAELAI
SACEFMFEETRNYVKQRKAFGKTVAHIQTVQHKLAELKTHICVTRAFVDSCLQLHETKRLDSGSASMAKYWASELQNSVAYECVQLHGGWGYMWEYPIAK
AYVDARVQPIYGGTNEIMKELIARQIVSDS
 
transit_peptide: 1..30
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (P51174.2)
calculated_mol_wt: 3274
peptide sequence: 
MAARLLLRSLRVLSARSAPRPLPSARCSHS

mat_peptide: 31..430
product: Long-chain specific acyl-CoA dehydrogenase, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P51174.2)
calculated_mol_wt: 44641
peptide sequence: 
GAEARLETPSAKKLTDIGIRRIFSSEHDIFRESVRKFFQEEVIPHHTEWEKAGEVSREVWEKAGKQGLLGINIAEKHGGIGGDLLSTAVTWEEQAYSNCT
GPGFSLHSDIVMPYIANYGTKEQIEKFIPQMTAGKCIGAIAMTEPGAGSDLQGVRTNAKRSGSDWILNGSKVFITNGWLSDLVIVVAVTNREARSPAHGI
SLFLVENGMKGFIKGRKLHKMGMKAQDTAELFFEDVRLPANALLGEENKGFYYLMQELPQERLLIAELAISACEFMFEETRNYVKQRKAFGKTVAHIQTV
QHKLAELKTHICVTRAFVDSCLQLHETKRLDSGSASMAKYWASELQNSVAYECVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKELIARQIVSDS